Y-Shaped Maze to Test Spontaneous Object Recognition and Temporal Order Memory After Traumatic Brain Injury

Hala Darwish; Hiba Hasan

doi:10.1007/978-1-4939-9554-7_22

Y-Shaped Maze to Test Spontaneous Object Recognition and Temporal Order Memory After Traumatic Brain Injury

Methods Mol Biol. 2019:2011:383-392. doi: 10.1007/978-1-4939-9554-7_22.

Authors

Hala Darwish¹, Hiba Hasan²

Affiliations

¹ Hariri School of Nursing, Anatomy, Cell Biology and Physiology Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. hd30@aub.edu.lb.
² Department of Biochemistry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

PMID: 31273711
DOI: 10.1007/978-1-4939-9554-7_22

Abstract

Traumatic brain injury (TBI) is one of the most frequent causes of brain damage. Cognitive deficits have been reported in the literature after mild-to-severe TBI affecting memory, language, executive functions, attention, and information processing speed. In this chapter, we describe a method to characterize cognitive impairment in rats following TBI of various intensities. The focus will be on spontaneous object recognition and temporal order memory in rats. These tests are performed in a Y-shaped maze. We have previously identified using this method persistent spontaneous object recognition and temporal order memory deficits following mild-to-moderate TBI in the animals up to 35-day postinjury.

Keywords: Memory deficits; Object recognition memory; Temporal order memory; Traumatic brain injury; Y-maze.

MeSH terms

Animals
Brain Injuries, Traumatic / complications*
Cognition
Cognition Disorders / diagnosis
Cognition Disorders / etiology*
Cognition Disorders / psychology*
Disease Models, Animal
Male
Maze Learning*
Memory
Memory Disorders / diagnosis
Memory Disorders / etiology*
Memory Disorders / psychology*
Rats