Metabolically Healthy Obesity and Bariatric Surgery

Obes Surg. 2019 Sep;29(9):2989-3000. doi: 10.1007/s11695-019-03964-8.

Abstract

A peculiar category of persons with obesity lacking common metabolic disturbances has been depicted and termed as metabolically healthy obesity (MHO). Yet, although MHO patients are free of obesity-associated complications, they might not be entirely precluded from developing cardio-metabolic disorders. Among patients with morbid obesity (MO) who are referred to bariatric surgery, a subset of metabolically healthy MO (MHMO) has been identified and the question arises if these patients would benefit from surgery in terms of mitigating the peril of cardio-metabolic complications. We revisited the pathophysiological mechanisms that define MHO, the currently available data on the cardio-metabolic risk of these patients and finally we reviewed the benefits of bariatric surgery and the urge to better characterize MHMO before submission to surgery.

Keywords: Bariatric surgery; Metabolically healthy obesity; Morbid obesity.

Publication types

  • Review

MeSH terms

  • Bariatric Surgery* / methods
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control*
  • Humans
  • Metabolic Diseases / etiology
  • Metabolic Diseases / prevention & control*
  • Obesity, Metabolically Benign / surgery*
  • Obesity, Morbid / classification
  • Obesity, Morbid / surgery*
  • Patient Selection
  • Risk Factors