Biochemometrics and Required Tools in Botanical Natural Products Research: A Review

Kevin M Wyss; Graham C Llivina; Angela I Calderón

doi:10.2174/1386207322666190704094003

Biochemometrics and Required Tools in Botanical Natural Products Research: A Review

Comb Chem High Throughput Screen. 2019;22(5):290-306. doi: 10.2174/1386207322666190704094003.

Authors

Kevin M Wyss¹, Graham C Llivina¹, Angela I Calderón¹

Affiliation

¹ Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, United States.

PMID: 31272351
DOI: 10.2174/1386207322666190704094003

Abstract

This review serves to highlight the role of chemometrics and biochemometrics in recent literature as well as including a perspective on the current state of the field, as well as the future needs and possible directions. Specifically examining the analytical methods and statistical tools that are available to chemists, current applications of QTOF-MS, Orbitrap-MS, LC with PDA/UV detectors, NMR, and IMS coupled MS are detailed. Of specific interest, these techniques can be applied to botanical dietary supplement quality, efficacy, and safety. Application in natural products drug discovery, industrial quality control, experimental design, and more are also discussed.

Keywords: Chemometrics; biochemometrics; botanical dietary supplements; massspectrometry; natural products; phytochemicals..

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Products*
Plants / chemistry*
Research / instrumentation
Research / trends*
Research Design

Substances

Biological Products