Directly Reprogrammed Neurons Still Have Some Growing Up to Do

Yichen Li; Justin K Ichida

doi:10.1016/j.stem.2019.06.005

Directly Reprogrammed Neurons Still Have Some Growing Up to Do

Cell Stem Cell. 2019 Jul 3;25(1):1-2. doi: 10.1016/j.stem.2019.06.005.

Authors

Yichen Li¹, Justin K Ichida²

Affiliations

¹ Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA 90033, USA.
² Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: ichida@usc.edu.

PMID: 31271745
DOI: 10.1016/j.stem.2019.06.005

Abstract

Direct lineage conversion offers a fast and simple method to study mature neurons in vitro, but its utility for investigating neurodevelopment has remained unclear. In this issue of Cell Stem Cell, Chanda et al. (2019) use Ngn2-induced neurons to elucidate the pathogenic mechanisms of the teratogenic compound valproic acid.

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MeSH terms

Calmodulin-Binding Proteins
Cell Differentiation
Humans
Membrane Proteins
Microfilament Proteins
Neurons*
Valproic Acid*

Substances

Calmodulin-Binding Proteins
MARCKSL1 protein, human
Membrane Proteins
Microfilament Proteins
Valproic Acid