Pandemic Uropathogenic Fluoroquinolone-resistant Escherichia coli Have Enhanced Ability to Persist in the Gut and Cause Bacteriuria in Healthy Women

Clin Infect Dis. 2020 Feb 14;70(5):937-939. doi: 10.1093/cid/ciz547.

Abstract

We report that fluoroquinolone-resistant Escherichia coli are found in feces of 8.8% of healthy women, with most bacteria belonging to pandemic multidrug-resistant ST131-H30R or ST1193 clonal groups. Moreover, these highly uropathogenic clonal groups demonstrate an especially prolonged gut persistence and high rate of bacteriuria without documented urinary tract infection.

Keywords: Escherichia coli; gut microflora; bacteriuria; fluoroquinolone resistance; urinary tract infections.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacteriuria* / drug therapy
  • Bacteriuria* / epidemiology
  • Drug Resistance, Multiple, Bacterial
  • Escherichia coli Infections* / drug therapy
  • Escherichia coli Infections* / epidemiology
  • Female
  • Fluoroquinolones / pharmacology
  • Gastrointestinal Microbiome*
  • Humans
  • Pandemics
  • Urinary Tract Infections* / drug therapy
  • Urinary Tract Infections* / epidemiology
  • Uropathogenic Escherichia coli*

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones