A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

Chem Commun (Camb). 2019 Jul 18;55(59):8564-8566. doi: 10.1039/c9cc03810h.

Abstract

Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.

MeSH terms

  • Biosensing Techniques / methods
  • Boron Compounds / chemical synthesis
  • Boron Compounds / chemistry*
  • Dipeptides
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Nanofibers / chemistry
  • Phenylalanine / analogs & derivatives*
  • Phenylalanine / analysis
  • Phenylalanine / chemistry
  • Protein Multimerization

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Dipeptides
  • Fluorescent Dyes
  • phenylalanylphenylalanine
  • Phenylalanine