Perplexing case of lung mass perfectly mimicking a malignancy

BMJ Case Rep. 2019 Jul 2;12(7):e229273. doi: 10.1136/bcr-2019-229273.

Abstract

A 35-year-old man, a known asthmatic and with a history of smoking presented with a history of recurrent episodes of mild haemoptysis. On examination, there was decreased intensity of breath sounds on the right infraclavicular area. The chest X-ray and CT chest showed a mass in right upper lobe with nodules in the other lobe. The VAT showed large heavily vascularised mass with surface laden with multiple nodules. The wedge resection of the mass was taken and sent for histopathology examination. The biopsy result showed picture suggestive of connective tissue disease associated follicular bronchiolitis. The patient did not have any signs or symptoms of connective tissue disease. However he was positive for Rheumatoid factor, ANA, anti-RO, anti-CCP antibodies. He was started on steroids and azathioprine. After 6 months of treatment, the size of the mass and nodules reduced by 50% and ESR was reduced to 5 from 75.

Keywords: bronchiolitis; connective tissue disease; interstitial lung disease; rheumatoid arthritis.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Azathioprine / therapeutic use
  • Biopsy
  • Bronchiolitis / complications*
  • Bronchiolitis / diagnostic imaging*
  • Bronchiolitis / drug therapy
  • Connective Tissue Diseases / complications*
  • Connective Tissue Diseases / diagnosis*
  • Connective Tissue Diseases / drug therapy
  • Diagnosis, Differential
  • Humans
  • Immunologic Factors / therapeutic use
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Neoplasms
  • Male
  • Prednisolone / therapeutic use
  • Rituximab / therapeutic use
  • Tomography, X-Ray Computed / methods*

Substances

  • Adrenal Cortex Hormones
  • Immunologic Factors
  • Rituximab
  • Prednisolone
  • Azathioprine