[Survival by cervical cancer stage and factors collected by the Cancer Registry in Mallorca (Spain)]

Abstract

Objective: To ascertain the survival by stage of cervical cancer in Mallorca (Spain), to explore factors collected by the Mallorcan Cancer Registry associated with survival, and to determine the distribution of cervical cases by stage.

Method: Retrospective follow-up study of cases diagnosed with cervical cancer between 2006 and 2012 through the Mallorcan Cancer Registry. Cases identified only by death certificate were excluded.

Variables: age; date and method of diagnosis; histology (ICD-O 3rd ed.); TNM and stage (UICC 7th ed.); date of follow-up or death and cause of death. Follow-up ended on 31 of December 2015. Multiple imputation was used for missing stage cases. Actuarial and Kaplan-Meier methods were used for survival analysis and Cox regression models to identify factors that explain and predict survival.

Results: 321 cases were identified. The stage was missing in 8.4% of cases. After multiple imputation, 42.63% were stage I, 24.01% stage II, 19.94% stage III and 13.42% stage IV. Survival was 63% at 5 years: 92% for women diagnosed in stage I, 59% in stage II, 37% in stage III and 18% in stage IV. Stage and age were associated to survival.

Conclusions: Diagnosis of cervical cancer in stage I is essential. Less than half of the women were diagnosed in stage I. Cervical cancer screening programmes must be improved.

Keywords: Cervical cancer; Cáncer de cuello uterino; Estadio; Imputación múltiple; Multiple imputation; Stage; Supervivencia; Survival.