Porous V2O5 microspheres are synthesized via spray-drying and employed as the cathode material for aqueous zinc-ion batteries (ZIBs). The obtained porous V2O5 microspheres exhibit an ultrahigh reversible capacity and superior rate and cycling performances. In particular, a discharge capacity of 401 mA h g-1 can be achieved at 100 mA g-1. The specific energy density reaches 286 W h kg-1, surpassing most reported V-based cathode materials. The super electrochemical performances demonstrate that the porous V2O5 microsphere is a promising cathode material for aqueous ZIBs.