Latest developments in molecular tracers for fluorescence image-guided cancer surgery

Lancet Oncol. 2019 Jul;20(7):e354-e367. doi: 10.1016/S1470-2045(19)30317-1.

Abstract

Real-time intraoperative guidance is essential during oncological surgery for complete and safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown potential for guiding surgeons during complex interventions. Recently, there has been a shift towards the use of fluorescence contrast agents for molecular imaging. The first targeted fluorescent agents, of which most consist of approved therapeutic antibodies conjugated to a fluorescent dye, have been evaluated in several early-phase clinical trials. Moreover, advances in protein engineering and drug design have led to the development of a variety of tracers suitable for molecular fluorescence image-guided surgery. In this Review, we discuss preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Clinical Trials as Topic
  • Fluorescence*
  • Fluorescent Dyes*
  • Forecasting
  • Humans
  • Intraoperative Care / methods*
  • Molecular Imaging / methods*
  • Neoplasms / diagnostic imaging*
  • Neoplasms / surgery*
  • Surgery, Computer-Assisted*

Substances

  • Fluorescent Dyes