Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

W A Sepúlveda Loyola; F Vilaça Cavallari Machado; L Araújo de Castro; T Hissnauer Leal Baltus; N Rampazzo Morelli; K Landucci Bonifácio; A A Morita; A P Michelin; D Sabbatini Barbosa; V S Probst

doi:10.1016/j.rce.2019.04.007

Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

Rev Clin Esp (Barc). 2019 Dec;219(9):477-484. doi: 10.1016/j.rce.2019.04.007. Epub 2019 Jun 29.

[Article in English, Spanish]

Affiliations

¹ Programa de Máster y Grado de Doctor en Ciencias de la Rehabilitación, Universidad Estatal de Londrina (UEL) y Universidad del Norte de Paraná (UNOPAR), Londrina, Brasil.
² Programa de Grado en Ciencias de la Salud, Universidad Estatal de Londrina (UEL), Paraná, Brasil.
³ Programa de Máster y Grado de Doctor en Ciencias de la Rehabilitación, Universidad Estatal de Londrina (UEL) y Universidad del Norte de Paraná (UNOPAR), Londrina, Brasil. Electronic address: vanessaprobst@gmail.com.

PMID: 31266638
DOI: 10.1016/j.rce.2019.04.007

Abstract

Objective: To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD.

Methods: Seventy-four subjects were included, 39 with COPD (age 69±7 years; female 41%) and 35 for control group (age 69±7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph.

Results: COPD severity (GOLD≥3) and pulmonary function were associated with sulfhydryl group and AOPP (P≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (P=.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P<.0001).

Conclusion: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD.

Keywords: Chronic obstructive pulmonary disease; Enfermedad pulmonar obstructiva crónica; Estrés oxidativo; Metabolic syndrome; Oxidative stress; Síndrome metabólico.