The Genome Sequence of the Anthelmintic-Susceptible New Zealand Haemonchus contortus

Genome Biol Evol. 2019 Jul 1;11(7):1965-1970. doi: 10.1093/gbe/evz141.

Abstract

Internal parasitic nematodes are a global animal health issue causing drastic losses in livestock. Here, we report a H. contortus representative draft genome to serve as a genetic resource to the scientific community and support future experimental research of molecular mechanisms in related parasites. A de novo hybrid assembly was generated from PCR-free whole genome sequence data, resulting in a chromosome-level assembly that is 465 Mb in size encoding 22,341 genes. The genome sequence presented here is consistent with the genome architecture of the existing Haemonchus species and is a valuable resource for future studies regarding population genetic structures of parasitic nematodes. Additionally, comparative pan-genomics with other species of economically important parasitic nematodes have revealed highly open genomes and strong collinearities within the phylum Nematoda.

Keywords: Haemonchus contortus; anthelmintic-susceptible; genome; helminth; parasite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / pharmacology*
  • Base Sequence
  • Genome, Helminth / genetics*
  • Genomics
  • Haemonchus / drug effects*
  • Haemonchus / genetics*
  • New Zealand

Substances

  • Anthelmintics