Two novel cyclic depsipeptides Xenematides F and G from the entomopathogenic bacterium Xenorhabdus budapestensis

Xuedong Xi; Xingzhong Lu; Xiaodong Zhang; Yuhui Bi; Xiaochun Li; Zhiguo Yu

doi:10.1038/s41429-019-0203-y

Two novel cyclic depsipeptides Xenematides F and G from the entomopathogenic bacterium Xenorhabdus budapestensis

J Antibiot (Tokyo). 2019 Oct;72(10):736-743. doi: 10.1038/s41429-019-0203-y. Epub 2019 Jul 2.

Authors

Xuedong Xi¹, Xingzhong Lu¹, Xiaodong Zhang¹, Yuhui Bi¹, Xiaochun Li¹, Zhiguo Yu²

Affiliations

¹ Department of Plant Protection, Shenyang Agricultural University, 110866, Liaoning Province, China.
² Department of Plant Protection, Shenyang Agricultural University, 110866, Liaoning Province, China. zyu@syau.edu.cn.

PMID: 31263151
DOI: 10.1038/s41429-019-0203-y

Abstract

Two novel depsipeptides xenematides F and G (1, 2), were isolated from entomopathogenic Xenorhabdus budapestensis SN84 along with a known compound xenematide B. The structures of the two new molecules were elucidated using NMR, MS and Marfey's method. The xenematide G (2) contains α-aminoheptanoic acid, a non-protein amino acid that is rarely found in secondary metabolites from entomopathogenic bacteria. Xenematides F and G were tested for antibacterial activity. Xenematide G (2) exhibited moderate antibacterial activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products / chemistry*
Biological Products / isolation & purification*
Depsipeptides / chemistry*
Depsipeptides / isolation & purification*
Molecular Structure
Spectrum Analysis
Xenorhabdus / chemistry*

Substances

Biological Products
Depsipeptides
xenematide

Supplementary concepts

Xenorhabdus budapestensis