The 4-H of Biomarkers in Arthritis: A Lot of Help, Occasional Harm, Some Hype, Increasing Hope

Gilles Boire; Hugues Allard-Chamard

doi:10.3899/jrheum.190375

The 4-H of Biomarkers in Arthritis: A Lot of Help, Occasional Harm, Some Hype, Increasing Hope

J Rheumatol. 2019 Jul;46(7):758-763. doi: 10.3899/jrheum.190375.

Authors

Gilles Boire^{1

2}, Hugues Allard-Chamard^{3

4}

Affiliations

¹ From the Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke; Department of Medicine, Centre intégré universitaire de Santé et de Services Sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l'Estrie-CHUS), Sherbrooke, Quebec, Canada. gilles.boire@usherbrooke.ca.
² H. Allard-Chamard, MD, PhD, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, and Department of Medicine, CIUSSS de l'Estrie-CHUS, currently Research Fellow in Medicine, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University; G. Boire, MD, MSc, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, and Department of Medicine, CIUSSS de l'Estrie-CHUS. gilles.boire@usherbrooke.ca.
³ From the Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke; Department of Medicine, Centre intégré universitaire de Santé et de Services Sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l'Estrie-CHUS), Sherbrooke, Quebec, Canada.
⁴ H. Allard-Chamard, MD, PhD, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, and Department of Medicine, CIUSSS de l'Estrie-CHUS, currently Research Fellow in Medicine, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University; G. Boire, MD, MSc, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, and Department of Medicine, CIUSSS de l'Estrie-CHUS.

PMID: 31262754
DOI: 10.3899/jrheum.190375

Abstract

(Gilles Boire): It was both a pleasure and an honor to present the 2019 Dunlop-Dottridge Lecture. My co-author and I will now discuss benefits and pitfalls of biomarkers developed through emerging techniques, evaluated through the experiential perspective of a seasoned clinician, as they apply to the quest for biomarker identification in rheumatic diseases.

Keywords: AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; ENVIRONMENT; GENETIC PREDISPOSITION TO DISEASE; OUTCOMES.

MeSH terms

Aged
Animals
Anti-Citrullinated Protein Antibodies / blood
Arthritis, Rheumatoid / blood
Arthritis, Rheumatoid / diagnosis*
Arthritis, Rheumatoid / physiopathology*
Base Sequence
Biomarkers*
Blood Sedimentation
C-Reactive Protein / analysis
Clinical Decision-Making / methods*
Cohort Studies
Disease Models, Animal
Female
Gastrointestinal Microbiome
Hope*
Humans
Male
Mice
Middle Aged
Rheumatologists / psychology

Substances

Anti-Citrullinated Protein Antibodies
Biomarkers
C-Reactive Protein