Predictive Potential of Head and Neck Squamous Cell Carcinoma Organoids

Sarah J Hill; Alan D D'Andrea

doi:10.1158/2159-8290.CD-19-0527

Predictive Potential of Head and Neck Squamous Cell Carcinoma Organoids

Cancer Discov. 2019 Jul;9(7):828-830. doi: 10.1158/2159-8290.CD-19-0527.

Authors

Sarah J Hill^{1

2}, Alan D D'Andrea^{3

2

4}

Affiliations

¹ Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
² Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
³ Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. alan_dandrea@dfci.harvard.edu.
⁴ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

PMID: 31262743
DOI: 10.1158/2159-8290.CD-19-0527

Abstract

In this issue of Cancer Discovery, Driehuis and colleagues establish culture conditions for the rapid, efficient, and long-term expansion of healthy human oral mucosa and head and neck squamous cell carcinoma (HNSCC) tumor organoids. The HNSCC tumor organoids provide a functional platform for analyzing tumor cell phenotype, tumorigenic potential, and drug and radiotherapy response, and they have a potential role in clinical decision-making.See related article by Driehuis et al., p. 852.

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MeSH terms

Carcinoma, Squamous Cell*
Head and Neck Neoplasms*
Humans
Mouth Mucosa
Organoids
Squamous Cell Carcinoma of Head and Neck*