Withaminimas A-F, six withanolides with potential anti-inflammatory activity from Physalis minima

Chin J Nat Med. 2019 Jun;17(6):469-474. doi: 10.1016/S1875-5364(19)30054-8.

Abstract

Withaminimas A-F (1-6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2-3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1-4 exhibited significant inhibitory effects with IC50 values among 3.91-18.46 μmol·L-1.

Keywords: Anti-inflammatory; Physalis minima; Withaphysalin-type withanolides.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / pharmacology*
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Macrophages / immunology
  • Mice
  • Molecular Structure
  • Physalis / chemistry*
  • RAW 264.7 Cells
  • Structure-Activity Relationship
  • Withanolides / chemistry*
  • Withanolides / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Drugs, Chinese Herbal
  • Lipopolysaccharides
  • Withanolides