Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

Nutrients. 2019 Jun 29;11(7):1483. doi: 10.3390/nu11071483.

Abstract

Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds.

Keywords: medicinal plants; phytotherapy; plant formulas; prostate cancer; secondary metabolites.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Animals
  • Antineoplastic Agents, Phytogenic / adverse effects
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Phytochemicals / adverse effects
  • Phytochemicals / therapeutic use*
  • Phytotherapy* / adverse effects
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / mortality
  • Prostatic Neoplasms / pathology
  • Risk Factors
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Phytogenic
  • Phytochemicals