Construct of MoSe2/Bi2Se3 nanoheterostructure: Multimodal CT/PT imaging-guided PTT/PDT/chemotherapy for cancer treating

Ying Wang; Jingxiang Zhao; Zhe Chen; Feng Zhang; Qian Wang; Wei Guo; Kai Wang; Huiming Lin; Fengyu Qu

doi:10.1016/j.biomaterials.2019.119282

Construct of MoSe₂/Bi₂Se₃ nanoheterostructure: Multimodal CT/PT imaging-guided PTT/PDT/chemotherapy for cancer treating

Biomaterials. 2019 Oct:217:119282. doi: 10.1016/j.biomaterials.2019.119282. Epub 2019 Jun 16.

Authors

Ying Wang¹, Jingxiang Zhao¹, Zhe Chen¹, Feng Zhang¹, Qian Wang¹, Wei Guo¹, Kai Wang², Huiming Lin³, Fengyu Qu⁴

Affiliations

¹ Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province and College of Chemistry and Chemical Engineering, Harbin Normal University, Heilongjiang, China.
² TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, And Molecular Imaging Research Center, Harbin Medical University, Heilongjiang, China. Electronic address: wangkai@hrbmu.edu.cn.
³ Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province and College of Chemistry and Chemical Engineering, Harbin Normal University, Heilongjiang, China. Electronic address: linhuiming@hrbnu.edu.cn.
⁴ Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province and College of Chemistry and Chemical Engineering, Harbin Normal University, Heilongjiang, China. Electronic address: qufengyu@hrbnu.edu.cn.

PMID: 31260884
DOI: 10.1016/j.biomaterials.2019.119282

Abstract

The development of nanotheranostic agent with imaging-guided highly therapeutic efficiency has attracted most attentions on tumor treatment. Herein, the novel MoSe₂/Bi₂Se₃ nanosheets were designed to integrate CT/photothermal (PT) imaging and photodynamic/photothermal/chemo-therapy (PTT/PDT/chemotherapy) into one nanoplatform. Firstly, the MoSe₂ nanosheets (5-30 nm) were prepared via ultrasound-assisted exfoliated method, and then by a cation-exchange strategy the novel sandwich nanostructure Bi₂Se₃/MoSe₂/Bi₂Se₃ (Bi-M-3) were obtained, revealing the narrower band gap (1.17 eV) and the stronger near-infrared (NIR) absorption. Both experimental and density functional theory (DFT) calculations reveal the Z-scheme mechanism of charge transfer in the heterostructure, which induces the enhanced ROS (⋅OH) generation due to the efficient separation of photogenerated electron-hole pairs. Meanwhile, the nanoheterostructure also makes sure the improved photothermal conversion efficiency (59.3%). Besides, we also found the photothermal effect can promote the transfer photo-generated electron that is in favor of ROS generation. Furthermore, because of the higher absorption coefficient of X-ray for Bi atom, the heterostructure also exhibits the higher CT imaging contrast than pure MoSe₂ sample. After the loading of anticancer drug Doxorubicin (Dox), Bi-M-3@PEG-Dox displays the acid/photothermal sensitive drug release behavior. The synergistic effect of chemotherapy, photodynamic and photothermal therapy further induces the superior cancer cell apoptosis and enhanced antitumor effect.

Keywords: CT/photothermal imaging; Cation-exchange; MoSe(2)/Bi(2)Se(3); Synergistic PTT/PDT/Chemotherapy; Z-scheme.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bismuth
Combined Modality Therapy
Hep G2 Cells
Humans
Hyperthermia, Induced*
Mice
Molybdenum / chemistry*
Multimodal Imaging
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Neoplasms / pathology
Neoplasms / therapy*
Organoselenium Compounds / chemistry*
Photochemotherapy*
Phototherapy*
Selenium Compounds
Spectrophotometry, Ultraviolet
Tomography, X-Ray Computed*

Substances

Organoselenium Compounds
Selenium Compounds
Molybdenum
bismuth selenide
Bismuth