Chronic TGF-β1 Signaling in Pulmonary Arterial Hypertension Induces Sustained Canonical Smad3 Pathways in Vascular Smooth Muscle Cells

Am J Respir Cell Mol Biol. 2019 Jul;61(1):121-123. doi: 10.1165/rcmb.2018-0275LE.

Authors

Laurent Calvier¹, Philippe Chouvarine¹, Ekaterina Legchenko¹, Gabor Kokeny², Miklos M Mozes², Georg Hansmann¹

Affiliations

¹ 1 Department of Pediatric Cardiology and Critical Care Hannover Medical School Hannover, Germany and.
² 2 Department of Pathophysiology Semmelweis University Budapest, Hungary.

PMID: 31259625
DOI: 10.1165/rcmb.2018-0275LE

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Male
Mice, Transgenic
Muscle, Smooth, Vascular / pathology*
Myocytes, Smooth Muscle / metabolism*
Pulmonary Arterial Hypertension / metabolism*
Rats, Sprague-Dawley
Signal Transduction*
Smad3 Protein / metabolism*
Transforming Growth Factor beta1 / metabolism*

Substances

Smad3 Protein
Transforming Growth Factor beta1