Fenton-Chemistry-Mediated Radical Polymerization

Abstract

In this review, the power of a classical chemical reaction, the Fenton reaction for initiating radical polymerizations, is demonstrated. The reaction between the Fenton reagents (i.e., Fe²⁺ and H₂ O₂ ) generates highly reactive hydroxyl radicals, which can act as radical initiators for the polymerization of vinyl monomers. Since the Fenton reaction is fast, easy to set up, cheap, and biocompatible, this unique chemistry is widely employed in various polymer synthesis studies via free radical polymerization or reversible addition-fragmentation chain transfer polymerization, and is utilized in a wide range of applications, such as the fabrication of biomaterials, hydrogels, and core-shell particles. Biologically activated Fenton-mediated radical polymerization, which can be performed in aerobic environments, are particularly useful for applications in biomedical systems.

Keywords: Fenton chemistry; RAFT polymerization; free radical polymerization; hydroxyl radicals.