Crimean-Congo Haemorrhagic Fever: Case study analysis of a sporadic outbreak from Chakwal, Pakistan

Zoonoses Public Health. 2019 Nov;66(7):871-873. doi: 10.1111/zph.12623. Epub 2019 Jul 1.

Abstract

Crimean-Congo Haemorrhagic Fever (CCHF) is a deadly viral zoonotic disease, which is endemic in Pakistan. We report a case study analysis of three cases of CCHF which occurred in Chakwal, Pakistan in 2016. The disease was suspected in three patients exhibiting clinical symptoms suggestive of CCHF; two of the three patients died. The presence of CCHF was detected by seroconversion (IgG) from the surviving patient, while the antigen was detected in Hyalomma ticks originating from animals in the vicinity. This report indicates increase threat emergence of CCHF in Pakistan and highlights its zoonotic implications requiring immediate interventions under the "One-Health" concept.

Keywords: Chakwal; Crimean-Congo Haemorrhagic Fever; ELISA.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Animals
  • Antibodies, Viral
  • Cities
  • Disease Outbreaks*
  • Fatal Outcome
  • Female
  • Hemorrhagic Fever Virus, Crimean-Congo / immunology
  • Hemorrhagic Fever, Crimean / epidemiology*
  • Hemorrhagic Fever, Crimean / mortality
  • Humans
  • Immunoglobulin G
  • Male
  • Middle Aged
  • Pakistan / epidemiology
  • Ticks / virology
  • Zoonoses

Substances

  • Antibodies, Viral
  • Immunoglobulin G