The use of topical Nitrosomonas eutropha for cosmetic improvement of facial wrinkles

J Cosmet Dermatol. 2020 Mar;19(3):689-693. doi: 10.1111/jocd.13060. Epub 2019 Jul 1.

Abstract

Background: Both topical and oral probiotics are becoming widely used. There is increasing interest in the cosmetic potential in topical probiotics. Nitrosomonas eutropha is an ammonia-oxidizing bacteria.

Aim: The purpose of this study was to assess whether there is any improvement in facial wrinkles with the use of Nitrosomonas eutropha, a topical probiotic.

Methods: In this prospective study, high-resolution photographs were obtained in twenty-nine participants at baseline and after using topical Nitrosomonas eutropha for seven days.

Results: There was a significant difference in wrinkle depth and severity in the high concentration probiotic group. There was also a statistically significant improvement in pigmentation of the forehead and glabella in the higher concentration group.

Conclusions: Nitrosomonas eutropha may have aesthetic benefits in terms of reducing the appearance of wrinkles. Larger studies with longer treatment and follow-up periods are required.

Keywords: photography; pigmentation; probiotics; wrinkles.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Aerosols / administration & dosage
  • Cosmetic Techniques*
  • Face
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitrosomonas*
  • Photography
  • Probiotics / administration & dosage*
  • Prospective Studies
  • Rejuvenation
  • Skin / diagnostic imaging
  • Skin Aging / physiology*
  • Treatment Outcome
  • Young Adult

Substances

  • Aerosols

Supplementary concepts

  • Nitrosomonas eutropha