A Review of Biologically Active Natural Products from a Desert Plant Cistanche tubulosa

Chem Pharm Bull (Tokyo). 2019;67(7):675-689. doi: 10.1248/cpb.c19-00008.

Abstract

An Orobanchaceae plant Cistanche tubulosa (SCHENK) WIGHT (Kanka-nikujuyou in Japanese), which is one of the authorized plant resources as Cistanches Herba in both Japanese and Chinese Pharmacopoeias, is a perennial parasitic plant growing on roots of sand-fixing plants. The stems of C. tubulosa have traditionally been used for treatment of impotence, sterility, lumbago, and body weakness as well as a promoting agent of blood circulation. In recent years, Cistanches Herba has also been widely used as a health food supplement in Japan, China, and Southeast Asian countries. Here we review our recent studies on chemical constituents from the stems of C. tubulosa as well as their bioactivities such as vasorelaxtant, hepatoprotective, and glucose tolerance improving effects.

Keywords: Cistanche tubulosa; Orobanchaceae; acteoside; echinacoside; kankanoside; phenylethanoid glycoside.

Publication types

  • Review

MeSH terms

  • Animals
  • Aorta, Thoracic / drug effects
  • Aorta, Thoracic / metabolism
  • Biological Products / chemistry*
  • Biological Products / isolation & purification
  • Biological Products / pharmacology
  • Cistanche / chemistry*
  • Cistanche / metabolism
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Monoterpenes / chemistry
  • Monoterpenes / isolation & purification
  • Monoterpenes / pharmacology
  • Plant Stems / chemistry
  • Plant Stems / metabolism
  • Protective Agents / chemistry
  • Protective Agents / isolation & purification
  • Protective Agents / pharmacology
  • Vasodilator Agents / chemistry
  • Vasodilator Agents / isolation & purification
  • Vasodilator Agents / pharmacology

Substances

  • Biological Products
  • Glycosides
  • Monoterpenes
  • Protective Agents
  • Vasodilator Agents