Glutaminostatin: Another facet of glucagon as a regulator of plasma amino acid concentrations

J Diabetes Investig. 2019 Nov;10(6):1391-1393. doi: 10.1111/jdi.13110. Epub 2019 Jul 25.

Abstract

Glucagon plays an essential role in robust feedback regulation between the liver and α-cells, and exerts suppressive or static effects on the plasma concentration of amino acids, especially glutamine. Thereby, "glutaminostatin" might be an alternative name in recognition of another facet of glucagon as a suppressor of plasma glutamine levels.

Publication types

  • Editorial

MeSH terms

  • Amino Acids / blood*
  • Gastrointestinal Agents / pharmacology*
  • Glucagon / pharmacology*
  • Glucagon-Secreting Cells / drug effects
  • Glucagon-Secreting Cells / metabolism*
  • Humans
  • Liver / drug effects
  • Liver / metabolism*

Substances

  • Amino Acids
  • Gastrointestinal Agents
  • Glucagon