Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis

Diaa I Osman; Said M El-Sheikh; Sheta M Sheta; Omnia I Ali; Aliaa M Salem; Wafaa Gh Shousha; Sherif F El-Khamisy; Sherif M Shawky

doi:10.1016/j.bios.2019.111451

Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis

Biosens Bioelectron. 2019 Sep 15:141:111451. doi: 10.1016/j.bios.2019.111451. Epub 2019 Jun 24.

Authors

Diaa I Osman¹, Said M El-Sheikh², Sheta M Sheta³, Omnia I Ali⁴, Aliaa M Salem², Wafaa Gh Shousha⁴, Sherif F El-Khamisy⁵, Sherif M Shawky⁶

Affiliations

¹ Clinical Biochemistry Department, National Liver Institute, Menoufia University, Menoufia, 32511, Egypt; Chemistry Department, Faculty of Science, Helwan University, Cairo, 11795, Egypt.
² Nanomaterials and Nanotechnology Department, Central Metallurgical R & D Institute, Cairo, 11421, Egypt.
³ Inorganic Chemistry Department, National Research Centre, 33 El-Behouth St., Dokki, Giza, 12622, Egypt. Electronic address: dr.sheta.nrc@gmail.com.
⁴ Chemistry Department, Faculty of Science, Helwan University, Cairo, 11795, Egypt.
⁵ Center of Genomics, Helmy Institute, Zewail City of Science and Technology, October Gardens, 6th of October City, 12578, Giza, Egypt; Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK.
⁶ Center of Genomics, Helmy Institute, Zewail City of Science and Technology, October Gardens, 6th of October City, 12578, Giza, Egypt; Biochemistry Department, Faculty of Pharmacy, Misr University for Science and Technology, 6th October City, Giza, 77, Egypt. Electronic address: sshawky@zewailcity.edu.eg.

PMID: 31252261
DOI: 10.1016/j.bios.2019.111451

Abstract

Development of ultra-sensitive, high specific and cost-effective nucleic acids (NAs) biosensors is critical for early diagnosis of cancer, genetic diseases and follows up response to treatment. Metal-organic frameworks (MOFs) as sensing materials underwent significant development in recent years due to their unique merits, such as structural diversity, tunable pore scale, large surface area, remarkable adsorption affinities, and good thermal stability. MOFs have shown potential contribution in nucleic acids biosensors research. Herein, a comprehensive overview on NAs biosensors state of the art based on MOFs has been discussed extensively, including different MOFs platforms sensing strategies (fluorescence, electrochemistry, electrochemiluminescence, and colorimetric techniques), their analytical performance and figures of merit in clinical diagnostics, with the future perspective in introducing MOFs in clinical laboratory diagnostics. Moreover, the different MOFs synthesis methods have been highlighted to serve as a guide for the researchers in selecting the appropriate platform that suits their research needs, and applications.

Keywords: Biosensors; Clinical applications; MOFs synthesis; Metal-organic frameworks; Nucleic acids.

Publication types

Review

MeSH terms

Animals
Biosensing Techniques / instrumentation
Biosensing Techniques / methods*
Clinical Laboratory Techniques / instrumentation
Clinical Laboratory Techniques / methods
Colorimetry / instrumentation
Colorimetry / methods
Electrochemical Techniques / instrumentation
Electrochemical Techniques / methods
Humans
Luminescent Measurements / instrumentation
Luminescent Measurements / methods
Metal-Organic Frameworks / chemistry*
Nucleic Acids / analysis*
Nucleic Acids / genetics

Substances

Metal-Organic Frameworks
Nucleic Acids