Achieving continuous manufacturing in lyophilization: Technologies and approaches

Roberto Pisano; Andrea Arsiccio; Luigi C Capozzi; Bernhardt L Trout

doi:10.1016/j.ejpb.2019.06.027

Achieving continuous manufacturing in lyophilization: Technologies and approaches

Eur J Pharm Biopharm. 2019 Sep:142:265-279. doi: 10.1016/j.ejpb.2019.06.027. Epub 2019 Jun 25.

Authors

Roberto Pisano¹, Andrea Arsiccio², Luigi C Capozzi², Bernhardt L Trout³

Affiliations

¹ Department of Applied Science and Technology, Politecnico di Torino, Torino 10129, Italy. Electronic address: roberto.pisano@polito.it.
² Department of Applied Science and Technology, Politecnico di Torino, Torino 10129, Italy.
³ Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

PMID: 31252071
DOI: 10.1016/j.ejpb.2019.06.027

Abstract

This paper provides an organic overview of the most interesting continuous freeze-drying concepts that have been proposed over the years. Attention has mainly been focused on the field of pharmaceuticals, but some background has also been given on the food industry. This work aims at providing a solid starting point for future research on continuous manufacturing for the freeze-drying of pharmaceuticals.

Keywords: Continuous; Drying; Freeze-drying; Freezing; Manufacturing.

Publication types

Review

MeSH terms

Food Industry / methods
Freeze Drying / methods*
Humans
Technology, Pharmaceutical / methods*