A sesquiterpene glycoside and phenylalanine derivatives from Tinospora sinensis

Fitoterapia. 2019 Sep:137:104247. doi: 10.1016/j.fitote.2019.104247. Epub 2019 Jun 24.

Abstract

A new sesquiterpene glycoside and a new amide have been isolated from the stems of Tinospora sinensis. Their structures were established by 2D NMR spectroscopic techniques (1H,1H-COSY, NOESY, HSQC and HMBC) and mass spectrometry. The isolated compounds were subjected to evaluate neuroprotective activities in vitro. The pre-treatment of two new compounds can significantly ameliorate damage of oxidative stress induced by Aβ25-35 and improve PC12 cells survival.

Keywords: Amide; Sesquiterpene glycoside; Tinospora sinensis.

MeSH terms

  • Amides / isolation & purification
  • Amides / pharmacology*
  • Animals
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Molecular Structure
  • Oxidative Stress / drug effects*
  • PC12 Cells
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Stems / chemistry
  • Rats
  • Reactive Oxygen Species / metabolism
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Tibet
  • Tinospora / chemistry*

Substances

  • Amides
  • Glycosides
  • Phytochemicals
  • Reactive Oxygen Species
  • Sesquiterpenes