Abstract
9 H-Cyclohepta[ b]pyridin-9-one was used as a diene cycloaddition partner to construct [3.2.2] bicycles in a copper-catalyzed [4+2] cycloaddition. Oxygen- and nitrogen-substituted terminal, disubstituted, trisubstituted, and cyclic alkenes reacted to afford the cycloadducts as single constitutional isomers in 48-80% yields and diastereomeric ratios up to 5.6:1.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry
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Benzopyrans / chemical synthesis*
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Benzopyrans / chemistry
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Catalysis
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Copper*
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Cycloaddition Reaction*
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Molecular Structure
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Pyridones / chemical synthesis*
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Pyridones / chemistry
Substances
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Alkenes
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Benzopyrans
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Pyridones
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Copper