Contrast Agents Based on Iron Oxide Nanoparticles for Clinical Magnetic Resonance Imaging

Bull Exp Biol Med. 2019 Jun;167(2):272-274. doi: 10.1007/s10517-019-04507-y. Epub 2019 Jun 26.

Abstract

Magnetic resonance imaging (MRI) is one of the most perspective methods of noninvasive visualization in medicine, and use of contrast agents significantly its potentialities extends. Iron oxide nanoparticles are promising contrast agents, but in fact all the data on their efficiency were obtained in high-field tomographs for experimental animals. We studied the possibility of using magnetic nanoparticles for MRI visualization of rat brain glioblastoma at the most common clinical field 1.5 T The data indicate the efficiency of iron oxide magnetic nanoparticles as contrast agents for 1.5 T MR tomographs.

Keywords: MRI; glioma; magnetic nanoparticles; tumor.

MeSH terms

  • Animals
  • Brain / diagnostic imaging
  • Cell Line, Tumor
  • Contrast Media / chemistry*
  • Ferric Compounds / chemistry*
  • Glioblastoma / diagnostic imaging*
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles / chemistry*
  • Rats

Substances

  • Contrast Media
  • Ferric Compounds
  • Magnetite Nanoparticles
  • ferric oxide