Abstract
New evidence on the role of H2S as a gasotransmitter suggests that the true signalling effectors are polysulfides. Both oxidized polysulfides and hydropolysulfides were synthesized and their presence in S. cerevisiae was observed for the first time. A single gene-deletant approach allowed observation of the modulation of polysulfide species and levels.
MeSH terms
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Carrier Proteins / genetics
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Cystathionine beta-Synthase / genetics
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Cystathionine gamma-Lyase / genetics
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Gasotransmitters / analysis*
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Gasotransmitters / chemical synthesis
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Gasotransmitters / metabolism
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Gene Deletion
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Metabolomics / methods
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Saccharomyces cerevisiae / chemistry*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / genetics
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Sulfides / analysis*
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Sulfides / chemical synthesis
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Sulfides / metabolism
Substances
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Carrier Proteins
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Gasotransmitters
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Saccharomyces cerevisiae Proteins
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Sulfides
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Tum1 protein, S cerevisiae
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polysulfide
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Cystathionine beta-Synthase
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CYS3 protein, S cerevisiae
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Cystathionine gamma-Lyase