Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder

William V McCall; Ruth M Benca; Meredith E Rumble; Doug Case; Peter B Rosenquist; Andrew D Krystal

doi:10.1016/j.jpsychires.2019.06.015

Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder

J Psychiatr Res. 2019 Sep:116:147-150. doi: 10.1016/j.jpsychires.2019.06.015. Epub 2019 Jun 19.

Authors

William V McCall¹, Ruth M Benca², Meredith E Rumble³, Doug Case⁴, Peter B Rosenquist⁵, Andrew D Krystal⁶

Affiliations

¹ The Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA. Electronic address: wmccall@augusta.edu.
² Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. Electronic address: rbenca@uci.edu.
³ Department of Psychiatry, University of Wisconsin, Madison, WI, USA. Electronic address: rumble@wisc.edu.
⁴ . Department of Biostatistics and Data Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: dcase@wakehealth.edu.
⁵ The Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA.
⁶ University of California San Francisco, San Francisco, CA, USA. Electronic address: andrew.krystal@ucsf.edu.

Abstract

In this paper, we report the rate of previously undiagnosed obstructive sleep apnea (OSA) in a randomized clinical trial (RCT) of suicidal patients with major depressive disorder (MDD). One hundred and twenty-five suicidal adults with MDD were recruited into a RCT. None were suspected to have OSA. Fourteen percent met diagnostic criteria for OSA. The Apnea Hypopnea Index (AHI) was predicted by increasing age, male sex, and higher Body Mass Index. However, neither the degree of daytime sleepiness nor the degree of insomnia predicted AHI severity. A high degree of suspicion is warranted for OSA in suicidal patients with MDD, and for patients with treatment-resistant depression. ClinicalTrials.gov identifier: NCT01689909.

Keywords: Major depressive disorder; Obstructive sleep apnea; Suicide; Treatment-resistance.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Comorbidity
Depressive Disorder, Major / epidemiology*
Depressive Disorder, Treatment-Resistant / epidemiology*
Female
Humans
Male
Middle Aged
Prevalence
Sleep Apnea, Obstructive / epidemiology*
Suicidal Ideation*

Associated data

ClinicalTrials.gov/NCT01689909

Abstract

Publication types

MeSH terms

Associated data

Grants and funding