State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

A Yu Mukhina; O A Medvedeva; M V Svishcheva; A V Shevchenko; N N Efremova; I I Bobyntsev; P V Kalutskii; L A Andreeva; N F Myasoedov

doi:10.1007/s10517-019-04496-y

State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment

Bull Exp Biol Med. 2019 Jun;167(2):226-228. doi: 10.1007/s10517-019-04496-y. Epub 2019 Jun 24.

Authors

A Yu Mukhina¹, O A Medvedeva¹, M V Svishcheva¹, A V Shevchenko¹, N N Efremova¹, I I Bobyntsev², P V Kalutskii¹, L A Andreeva³, N F Myasoedov³

Affiliations

¹ Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
² Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. bobig@mail.ru.
³ Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

PMID: 31236882
DOI: 10.1007/s10517-019-04496-y

Abstract

We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.

Keywords: Selank; dysbiosis; microbiota; restraint stress.

MeSH terms

Animals
Colon / microbiology*
Disease Models, Animal
Gastrointestinal Microbiome / drug effects*
Male
Oligopeptides / therapeutic use*
Rats
Rats, Wistar
Restraint, Physical / physiology*

Substances

Oligopeptides
TP 7