Osteochondral defects is a common clinical joint disease. The complexity of cartilage-bone interface and the poor self-repair capacity of cartilage are both reasons for current relatively limited clinical treatments. The introduction of tissue engineering provides a new treatment method for osteochondral repair. This paper reviews three main elements of cartilage-bone tissue engineering: seed cell source and culture method, cytokines regulation and synergistic effect, and scaffold components and type. We mainly focused on current status quo and future progress of cartilage-bone repair scaffolds. This paper provides some reference for the further development of osteochondral tissue engineering.
骨软骨损伤是临床上常见的关节疾病。由于骨软骨界面的复杂性和软骨自我修复能力匮乏等因素，针对骨软骨损伤的临床治疗局限性较大。组织工程的提出，为骨软骨损伤同步修复提供了新的治疗方式。本文就骨软骨组织工程的三个方面进行综述介绍，它们分别是：种子细胞来源以及培养方式、生长因子的调控以及协同作用、细胞支架的组成类型，文中着重探讨骨软骨修复支架的现状和研究进展，最终期待通过本文综述，可为骨软骨组织工程的进一步发展提供参考。.
Keywords: cytokines; osteochondral defects; scaffolds; seeding cells; tissue-engineering.