Critical review: Typical and atypical optic neuritis

Anne Abel; Collin McClelland; Michael S Lee

doi:10.1016/j.survophthal.2019.06.001

Critical review: Typical and atypical optic neuritis

Surv Ophthalmol. 2019 Nov-Dec;64(6):770-779. doi: 10.1016/j.survophthal.2019.06.001. Epub 2019 Jun 20.

Authors

Anne Abel¹, Collin McClelland², Michael S Lee³

Affiliations

¹ Department of Ophthalmology, Hennepin Healthcare, Minneapolis, Minnesota, USA; Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
² Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
³ Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA; Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: mikelee@umn.edu.

PMID: 31229520
DOI: 10.1016/j.survophthal.2019.06.001

Abstract

Typical optic neuritis is an idiopathic demyelinating condition that is often associated with multiple sclerosis. This has been well characterized and has an excellent prognosis. Atypical optic neuritis can result from an inflammatory, infectious, or autoimmune disorder. Differentiating the two types of optic neuritis is paramount and may be challenging early on in the clinical course. This review describes the recent literature describing the pathophysiology, clinical presentation, neuroimaging, and management of these disorders.

Keywords: infectious optic neuritis; inflammatory optic neuritis; multiple sclerosis; myelin oligodendrocyte glycoprotein antibody; neuromyelitis optica; optic neuritis; optic perineuritis.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Autoimmune Diseases / complications
Diagnosis, Differential
Humans
Multiple Sclerosis / complications
Optic Nerve / pathology
Optic Neuritis* / diagnostic imaging
Optic Neuritis* / physiopathology
Optic Neuritis* / therapy
Prognosis
Visual Acuity

Substances

Adrenal Cortex Hormones