Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer

Bhagyashri Kulkarni; Prathibha Kirave; Piyush Gondaliya; Kavya Jash; Alok Jain; Rakesh K Tekade; Kiran Kalia

doi:10.1016/j.drudis.2019.06.010

Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer

Drug Discov Today. 2019 Oct;24(10):2058-2067. doi: 10.1016/j.drudis.2019.06.010. Epub 2019 Jun 19.

Authors

Bhagyashri Kulkarni¹, Prathibha Kirave¹, Piyush Gondaliya¹, Kavya Jash¹, Alok Jain¹, Rakesh K Tekade², Kiran Kalia³

Affiliations

¹ National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air force station, Gandhinagar, 382355, Gujarat, India.
² National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air force station, Gandhinagar, 382355, Gujarat, India; Department of Materials Science Engineering, Indian Institute of Technology-Jammu, Jagti, PO Nagrota, Jammu - 181 221, J&K, India. Electronic address: rakeshtekade@gmail.com.
³ National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air force station, Gandhinagar, 382355, Gujarat, India. Electronic address: kirankalia@gmail.com.

PMID: 31228614
DOI: 10.1016/j.drudis.2019.06.010

Abstract

In the treatment of cancer, there are three significant limitations causing high mortality and recurrence rates among cancer patients. First, the escape of tumor cells from the immune system; second, the development of multi-drug resistance (MDR) to chemotherapeutic drugs; and, third, the noxious metastases of cancer cells. Exosomes are vesicular cargos involved in the transportation of miRNA, mRNA and proteins from one cell to another cell. This review details the current understanding of the exosomal transmission of miRNA and crosstalk with the downstream consequences, ultimately leading to the progression and metastasis of cancer. Further, this review also discusses how exosomal miRNA can provide promising novel targets for the treatment and detection of cancer.

Publication types

Review

MeSH terms

Drug Discovery / methods*
Drug Resistance, Neoplasm / drug effects*
Drug Resistance, Neoplasm / genetics*
Exosomes / drug effects
Exosomes / genetics*
Humans
Immune Evasion / drug effects
Immune Evasion / genetics*
MicroRNAs / drug effects
MicroRNAs / genetics*
Models, Biological
Neoplasm Metastasis / drug therapy
Neoplasm Metastasis / genetics*
Neoplasms / drug therapy
Neoplasms / genetics*
Neoplasms / pathology*

Substances

MicroRNAs