Increased extracellular maspin levels after mechanical compression in vitro or allergen challenge in vivo

Sae-Hoon Kim; Jennifer A Mitchel; Maureen McGill; Tiziana P Cremona; Ji Won Baek; David I Kasahara; Vikas Anathy; Elliot Israel; Jin-Ah Park

doi:10.1016/j.jaci.2019.06.006

Increased extracellular maspin levels after mechanical compression in vitro or allergen challenge in vivo

J Allergy Clin Immunol. 2019 Oct;144(4):1116-1118.e4. doi: 10.1016/j.jaci.2019.06.006. Epub 2019 Jun 19.

Authors

Sae-Hoon Kim¹, Jennifer A Mitchel², Maureen McGill², Tiziana P Cremona², Ji Won Baek², David I Kasahara², Vikas Anathy³, Elliot Israel⁴, Jin-Ah Park⁵

Affiliations

¹ Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass; Department of Internal Medicine, Seoul National University Bundang University Hospital, Seoul, Korea.
² Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass.
³ Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, Vt.
⁴ Brigham and Women's Hospital, Boston, Mass.
⁵ Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass. Electronic address: jpark@hsph.harvard.edu.

Abstract

Maspin secretion from bronchial epithelial cells is substantially elevated by mechanical compression and in BAL fluid of patients with asthma following an allergen challenge, suggesting a potential role of maspin in asthma pathophysiology.

Publication types

Letter

MeSH terms

Airway Remodeling / immunology*
Allergens / immunology
Animals
Asthma / immunology*
Asthma / physiopathology
Cells, Cultured
Humans
Mice
Physical Stimulation
Respiratory Mucosa / immunology*
Respiratory Mucosa / metabolism
Serpins / immunology*

Substances

Allergens
SERPIN-B5
Serpins

Abstract

Publication types

MeSH terms

Substances

Grants and funding