Disseminated metastatic cutaneous melanoma to pancreas and upper gastrointestinal tract diagnosed by endoscopic ultrasound: an unusual case

Clin J Gastroenterol. 2020 Feb;13(1):134-138. doi: 10.1007/s12328-019-01004-7. Epub 2019 Jun 21.

Abstract

There is a wide variety of pancreatic neoplasms identified, but the great majority of them are of primary origin. Metastatic disease in the pancreatic parenchyma is quite rare (2-5% of pancreatic malignancies) and most often is quite difficult to differentiate from other primary lesions. Most of the imaging studies fail to give certain discriminating features for metastatic pancreatic neoplasms, contrary to endoscopic ultrasound and tissue sampling, which can provide an accurate diagnosis. In this report, we present a case of a male middle aged man who was admitted to our hospital with painless jaundice and finally was diagnosed with a cutaneous scalp melanoma dispersedly metastasized to the pancreas and upper gastrointestinal tract (stomach and duodenum).

Keywords: Endoscopic ultrasound; Endoscopic ultrasound fine-needle biopsy; Pancreatic metastatic melanoma.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / drug therapy
  • Adrenal Gland Neoplasms / secondary
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms / secondary
  • Brain Neoplasms / therapy
  • Cholangiopancreatography, Endoscopic Retrograde
  • Cranial Irradiation
  • Duodenal Neoplasms / diagnostic imaging
  • Duodenal Neoplasms / drug therapy
  • Duodenal Neoplasms / pathology
  • Duodenal Neoplasms / secondary*
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration
  • Endoscopy, Digestive System
  • Endosonography
  • Humans
  • Imidazoles / administration & dosage
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary
  • Male
  • Melanoma / diagnostic imaging
  • Melanoma / pathology
  • Melanoma / secondary*
  • Melanoma / therapy
  • Middle Aged
  • Oximes / administration & dosage
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / drug therapy
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / secondary*
  • Pyridones / administration & dosage
  • Pyrimidinones / administration & dosage
  • Skin Neoplasms / pathology*
  • Stomach Neoplasms / diagnostic imaging
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / secondary*
  • Tomography, X-Ray Computed

Substances

  • Imidazoles
  • Oximes
  • Pyridones
  • Pyrimidinones
  • trametinib
  • dabrafenib