Abstract
The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly process has shown clinical efficacy in early clinical trials. Herein is described the SAR exploration of NVR 3-778, the first clinical compound in the sulfonyl carboxamide class.
Keywords:
Capsid modulator; Core protein; HBV; Sulfonamide.
Copyright © 2019 Elsevier Ltd. All rights reserved.
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Benzamides / chemical synthesis
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Benzamides / chemistry
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Benzamides / pharmacology*
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Capsid Proteins / antagonists & inhibitors*
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Capsid Proteins / metabolism
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Dose-Response Relationship, Drug
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Hepatitis B virus / drug effects*
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Hepatitis B virus / metabolism
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Piperidines / chemical synthesis
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Piperidines / chemistry
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Piperidines / pharmacology*
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Structure-Activity Relationship
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Virus Assembly / drug effects
Substances
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Antiviral Agents
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Benzamides
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Capsid Proteins
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NVR 3-778
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Piperidines