Preparation of hydrophobic La2Mo2O9 ceramics with antibacterial and antiviral properties

Takumi Matsumoto; Kayano Sunada; Takeshi Nagai; Toshihiro Isobe; Sachiko Matsushita; Hitoshi Ishiguro; Akira Nakajima

doi:10.1016/j.jhazmat.2019.05.003

Preparation of hydrophobic La₂Mo₂O₉ ceramics with antibacterial and antiviral properties

J Hazard Mater. 2019 Oct 15:378:120610. doi: 10.1016/j.jhazmat.2019.05.003. Epub 2019 Jun 7.

Authors

Takumi Matsumoto¹, Kayano Sunada², Takeshi Nagai², Toshihiro Isobe³, Sachiko Matsushita¹, Hitoshi Ishiguro², Akira Nakajima⁴

Affiliations

¹ Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8552, Japan.
² Antibacterial and Antiviral Research Group, Kanagawa Institute of Industrial Science and Technology, LiSE4c-1, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan.
³ Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8552, Japan. Electronic address: isobe.t.ad@m.titech.ac.jp.
⁴ Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8552, Japan. Electronic address: anakajim@ceram.titech.ac.jp.

PMID: 31226590
DOI: 10.1016/j.jhazmat.2019.05.003

Abstract

After powder of La₂Mo₂O₉ (LMO) was prepared using complex polymerization, dense sintered bodies (96% relative density) of LMO were obtained from the powder through pressureless sintering in a synthesized air atmosphere. The water contact angle of the LMO ceramics increased gradually during storage in ambient air. It reached 93.6 ± 3.0° in 624 h. Results of XPS analysis and ozone treatment suggest that organic substances in ambient air adsorbed onto the LMO surface during storage. Measurements of antibacterial (Escherichia coli and Staphylococcus aureus) and antiviral (bacteriophage Qβ and bacteriophage Φ6) activities of LMO revealed that their survival rates decreased more than 99.9% within 6 h. Based on results obtained using dissolved ion contact method and from comparison of the antibacterial and antiviral activities with La₂O₃ and MoO₃, one can infer that the synergistic effect of La₂O₃ and MoO₃ plays an important role in the high antibacterial and antiviral activity of LMO.

Keywords: Antibacterial; Antiviral; Hydrophobic; La(2)Mo(2)O(9).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Antiviral Agents / pharmacology*
Carbon / chemistry
Ceramics / chemistry*
Drug Design
Drug Evaluation, Preclinical
Escherichia coli / drug effects
Ions
Lanthanum / chemistry*
Microbial Sensitivity Tests
Molybdenum / chemistry
Polymerization
Powders
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus / drug effects
Water / pharmacology
X-Ray Diffraction

Substances

Anti-Bacterial Agents
Antiviral Agents
Ions
Powders
Water
lanthanide nitrate
Lanthanum
Carbon
Molybdenum