Application of Deep Learning in Quantitative Analysis of 2-Dimensional Ultrasound Imaging of Nonalcoholic Fatty Liver Disease

Abstract

Objectives: To verify the value of deep learning in diagnosing nonalcoholic fatty liver disease (NAFLD) by comparing 3 image-processing techniques.

Methods: A total of 240 participants were recruited and divided into 4 groups (normal, mild, moderate, and severe NAFLD groups), according to the definition and the ultrasound scoring system for NAFLD. Two-dimensional hepatic imaging was analyzed by the envelope signal, grayscale signal, and deep-learning index obtained by 3 image-processing techniques. The values of the 3 methods ranged from 0 to 65,535, 0 to 255, and 0 to 4, respectively. We compared the values among the 4 groups, draw receiver operating characteristic curves, and compared the area under the curve (AUC) values to identify the best image-processing technique.

Results: The envelope signal value, grayscale value, and deep-learning index had a significant difference between groups and increased with the severity of NAFLD (P < .05). The 3 methods showed good ability (AUC > 0.7) to identify NAFLD. Meanwhile, the deep-learning index showed the superior diagnostic ability in distinguishing moderate and severe NAFLD (AUC = 0.958).

Conclusions: The envelope signal and grayscale values were vital parameters in the diagnosis of NAFLD. Furthermore, deep learning had the best sensitivity and specificity in assessing the severity of NAFLD.

Keywords: deep-learning index; envelope signal; grayscale; nonalcoholic fatty liver disease.