Facile strategy to construct a self-healing and biocompatible cellulose nanocomposite hydrogel via reversible acylhydrazone

Guifa Xiao; Ying Wang; Hui Zhang; Liheng Chen; Shiyu Fu

doi:10.1016/j.carbpol.2019.04.080

Facile strategy to construct a self-healing and biocompatible cellulose nanocomposite hydrogel via reversible acylhydrazone

Carbohydr Polym. 2019 Aug 15:218:68-77. doi: 10.1016/j.carbpol.2019.04.080. Epub 2019 Apr 26.

Authors

Guifa Xiao¹, Ying Wang¹, Hui Zhang¹, Liheng Chen², Shiyu Fu³

Affiliations

¹ State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
² Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
³ State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address: shyfu@scut.edu.cn.

PMID: 31221345
DOI: 10.1016/j.carbpol.2019.04.080

Abstract

Facile strategy to construct a cellulose nanocomposite hydrogel with self-healing and biocompatible properties is reported by crosslinking dialdehyde cellulose nanocrystals with acylhydrazine-terminated polyethylene glycol via dynamic reversible acylhydrazone for the first time. The effects of process variables on gelation time, mechanical strength and self-healing efficiency of hydrogels were investigated. It was found that gelation time shortened from hours to seconds by adjusting gelator and catalyst concentration. Tensile and compressive strength of hydrogel could reach 141 K Pa and 580 K Pa at 20.1% gelator concentration, respectively. Interestingly, the as-prepared hydrogel presented excellent self-healing ability without additional stimuli whose healing efficiency was higher than 90% even at higher gelator concentration. Furthermore, Cytotoxicity test showed that cell viability almost reached 100% after culturing with hydrogel, which revealed the hydrogel was biocompatible.

Keywords: Acylhydrazone; Biocompatibility; Dialdehyde cellulose nanocrystals; Hydrogel; Self-healing ability.

MeSH terms

Animals
Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry*
Biocompatible Materials / toxicity
Cell Line
Cellulose / chemical synthesis
Cellulose / chemistry*
Cellulose / toxicity
Compressive Strength
Hydrazones / chemical synthesis
Hydrazones / chemistry*
Hydrazones / toxicity
Hydrogels / chemical synthesis
Hydrogels / chemistry*
Hydrogels / toxicity
Hydrogen-Ion Concentration
Mice
Nanocomposites / chemistry*
Nanocomposites / toxicity
Polyethylene Glycols / chemistry
Polyethylene Glycols / toxicity
Tensile Strength

Substances

Biocompatible Materials
Hydrazones
Hydrogels
Polyethylene Glycols
Cellulose