The Avidity Game: Selecting Natural-Born Killers

Christopher E Andoniou; Iona S Schuster; Mariapia A Degli-Esposti

doi:10.1016/j.immuni.2019.05.018

The Avidity Game: Selecting Natural-Born Killers

Immunity. 2019 Jun 18;50(6):1337-1339. doi: 10.1016/j.immuni.2019.05.018.

Authors

Christopher E Andoniou¹, Iona S Schuster¹, Mariapia A Degli-Esposti²

Affiliations

¹ Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; Centre for Experimental Immunology, Lions Eye Institute, Perth, WA, Australia.
² Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; Centre for Experimental Immunology, Lions Eye Institute, Perth, WA, Australia. Electronic address: mariapia.degli-esposti@monash.edu.

PMID: 31216454
DOI: 10.1016/j.immuni.2019.05.018

Abstract

Natural killer (NK) cells display some features equivalent to those of adaptive immune effectors, but the molecular processes underlying these adaptive-like characteristics are just beginning to be defined. In this issue of Immunity, Adams et al. (2019) and Grassmann et al. (2019) report that avidity selection for Ly49H governs the expansion, differentiation, and function of NK cells after cytomegalovirus infection.

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MeSH terms

Cell Differentiation
Cytomegalovirus Infections*
Humans
Killer Cells, Natural