New keys for old locks: carborane-containing drugs as platforms for mechanism-based therapies

Chem Soc Rev. 2019 Jul 1;48(13):3497-3512. doi: 10.1039/c9cs00197b.

Abstract

Icosahedral carboranes in medicine are still an emerging class of compounds with potential beneficial applications in drug design. These highly hydrophobic clusters are potential "new keys for old locks" which open up an exciting field of research for well-known, but challenging important therapeutic substrates, as demonstrated by the numerous examples discussed in this review.

Publication types

  • Review

MeSH terms

  • Animals
  • Boranes / chemistry*
  • Boranes / pharmacology
  • Drug Design
  • Enzymes / metabolism
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Hypoxia-Inducible Factor 1 / metabolism
  • Ligands
  • Receptors, Androgen / metabolism
  • Receptors, Calcitriol / metabolism
  • Receptors, Estrogen / metabolism
  • Receptors, Purinergic / metabolism

Substances

  • Boranes
  • Enzymes
  • Hypoxia-Inducible Factor 1
  • Ligands
  • Receptors, Androgen
  • Receptors, Calcitriol
  • Receptors, Estrogen
  • Receptors, Purinergic