MicroRNAs, intestinal inflammatory and tumor

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2051-2058. doi: 10.1016/j.bmcl.2019.06.013. Epub 2019 Jun 12.

Abstract

Colorectal cancer (CRC) is the third most malignant tumor. Inflammatory bowel disease (IBD) can increase the risk of colorectal cancer. And colitis-associated cancer (CAC) is a CRC subtype, representing the inflammation-related colorectal cancer. For the past decades, we have known that ectopic microRNA (miRNA) expression was involved in the pathogenesis of IBD and CRC, playing a pivotal role in the progression of inflammation to colorectal cancer. Thus, this review provides the recent advances in altered human tissue-specific miRNAs that contribute to IBD, CRC and CAC pathogenesis, diagnosis and treatment. Meanwhile, the potential utilization of miRNAs as novel therapeutic targets for the prevention of CRC was also discussed.

Keywords: CAC; CRC; IBD; miR-19a; miR-21; miR-31; miRNAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Colitis / genetics
  • Colitis / physiopathology*
  • Colorectal Neoplasms / etiology
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / physiopathology*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Inflammation / complications
  • MicroRNAs / metabolism*

Substances

  • MicroRNAs