cGAS-independent STING activation in response to DNA damage

Leonie Unterholzner; Gillian Dunphy

doi:10.1080/23723556.2018.1558682

cGAS-independent STING activation in response to DNA damage

Mol Cell Oncol. 2019 Apr 19;6(4):1558682. doi: 10.1080/23723556.2018.1558682. eCollection 2019.

Authors

Leonie Unterholzner¹, Gillian Dunphy¹

Affiliation

¹ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.

Abstract

Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).

Keywords: DNA damage; IFI16; STING; etoposide; innate immunity.

Abstract

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