Regulatory interplay between deubiquitinating enzymes and cytokines

Bean Woo; Kwang-Hyun Baek

doi:10.1016/j.cytogfr.2019.06.001

Regulatory interplay between deubiquitinating enzymes and cytokines

Cytokine Growth Factor Rev. 2019 Aug:48:40-51. doi: 10.1016/j.cytogfr.2019.06.001. Epub 2019 Jun 8.

Authors

Bean Woo¹, Kwang-Hyun Baek²

Affiliations

¹ Department of Biomedical Science, CHA University, Bundang CHA General Hospital, Gyeonggi-Do, 13488, Republic of Korea; University of Alabama at Birmingham School of Medicine, Birmingham, AL, 35233, USA.
² Department of Biomedical Science, CHA University, Bundang CHA General Hospital, Gyeonggi-Do, 13488, Republic of Korea. Electronic address: baek@cha.ac.kr.

Abstract

Deubiquitinating enzymes (DUBs) are cysteine protease proteins that reverse the ubiquitination by removing ubiquitins from the target protein. With over 100 DUBs identified and categorized into at least 7 families, many DUBs interact with one or more cytokines, influencing cellular processes, such as antiviral responses, inflammatory responses, apoptosis, etc. While some DUBs influence cytokine pathway or production, some DUBs are cytokine-inducible. In this article, we summarize a list of DUBs, their interaction with cytokines, target proteins and mechanisms of action.

Keywords: Cytokine-inducible; DUB; IFN; Interleukin; TNF; Ubiquitination.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cytokines / metabolism*
Deubiquitinating Enzymes / metabolism*
Humans
Signal Transduction

Substances

Cytokines
Deubiquitinating Enzymes