Antioxidant activities and molecular docking of 2-thioxobenzo[g]quinazoline derivatives

Rashad Al-Salahi; Hanan A A Taie; Ahmed H Bakheit; Mohamed Marzouk; Abdulrahman A Almehizia; Rashed Herqash; Hatem A Abuelizz

doi:10.1016/j.pharep.2019.04.003

Antioxidant activities and molecular docking of 2-thioxobenzo[g]quinazoline derivatives

Pharmacol Rep. 2019 Aug;71(4):695-700. doi: 10.1016/j.pharep.2019.04.003. Epub 2019 Apr 9.

Authors

Rashad Al-Salahi¹, Hanan A A Taie², Ahmed H Bakheit³, Mohamed Marzouk⁴, Abdulrahman A Almehizia⁵, Rashed Herqash⁵, Hatem A Abuelizz⁵

Affiliations

¹ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: ralsalahi@ksu.edu.sa.
² Plant Biochemistry Department, Division of Agriculture and Biological Researches, National Research Centre, Giza, Egypt.
³ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, El-Neelain University, Khartoum, Sudan.
⁴ Chemistry of Natural Products Group, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, Egypt.
⁵ Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

PMID: 31207430
DOI: 10.1016/j.pharep.2019.04.003

Abstract

Background: Oxidative stress and related diseases resulting from the overproduction of free radicals can be counteracted by designing and developing novel antioxidative agents that can protect the human body against the damage caused by free radicals.

Methods: The present study evaluated the antioxidant activities of 15 derivatives of 2-thioxobenzo[g]quinazoline using three different assays: 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, reducing power capability, and ferric reduction antioxidant power.

Results: Some benzoquinazolines had good activity and had the capacity to deplete DPPH and free radicals compared to a positive control butylated hydroxyl toluene (BHT). A docking study identified the possible interactions between binding models and the antioxidant activities of the target compounds.

Conclusions: The active compounds can be used as templates for further development of more potent antioxidative agents.

Keywords: Antioxidant capacity; BHT; Benzoquinazolines; DPPH; Molecular docking; Reducing power.

MeSH terms

Antioxidants / chemistry*
Antioxidants / pharmacology*
Binding Sites
Biphenyl Compounds / chemistry*
Chlorides / chemistry*
Ferric Compounds / chemistry*
Free Radicals / chemistry*
Molecular Docking Simulation
Molecular Structure
Oxidation-Reduction
Picrates / chemistry*
Quinazolines / chemistry*
Quinazolines / pharmacology*

Substances

Antioxidants
Biphenyl Compounds
Chlorides
Ferric Compounds
Free Radicals
Picrates
Quinazolines
1,1-diphenyl-2-picrylhydrazyl
ferric chloride