SPTBN1 and cancer, which links?

Shuyi Chen; Jiajia Li; Ping Zhou; Xiuling Zhi

doi:10.1002/jcp.28975

SPTBN1 and cancer, which links?

J Cell Physiol. 2020 Jan;235(1):17-25. doi: 10.1002/jcp.28975. Epub 2019 Jun 17.

Authors

Shuyi Chen¹, Jiajia Li², Ping Zhou¹, Xiuling Zhi¹

Affiliations

¹ Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
² Department of Gynecology, Affiliated Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

PMID: 31206681
DOI: 10.1002/jcp.28975

Abstract

SPTBN1 is a dynamic intracellular nonpleckstrin homology-domain protein, functioning as a transforming growth factor-β signal transducing adapter protein which is necessary to form Smad3/Smad4 complex. Recently SPTBN1 is considered to be associated with many kinds of cancers. SPTBN1 expression and function differ between different tumor states or types. This review summarizes the recent advances in the expression patterns of SPTBN1 in cancers, and in understanding the mechanisms by which SPTBN1 affects the occurrence, progression, and metastasis of cancer. Identifying SPTBN1 expression and function in cancers will contribute to the clinical diagnosis and treatment of cancer and the investigation of anticancer drugs.

Keywords: DNA repair; SPTBN1; TGF-β signal pathway; Wnt signal pathway; cancer; epithelial-mesenchymal transition (EMT).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents
Gene Expression Regulation, Neoplastic / physiology*
Humans
Neoplasms / classification
Neoplasms / metabolism*
Spectrin / genetics
Spectrin / metabolism*

Substances

Antineoplastic Agents
SPTBN1 protein, human
Spectrin