Dataset on transcriptome profiling of corneal endothelium from patients with Fuchs endothelial corneal dystrophy

Anastasia S Nikitina; Alexandra V Belodedova; Boris E Malyugin; Elena I Sharova; Elena S Kostryukova; Andrey K Larin; Vladimir A Veselovsky; Olga P Antonova; Liubov O Skorodumova

doi:10.1016/j.dib.2019.104047

Dataset on transcriptome profiling of corneal endothelium from patients with Fuchs endothelial corneal dystrophy

Data Brief. 2019 May 23:25:104047. doi: 10.1016/j.dib.2019.104047. eCollection 2019 Aug.

Authors

Anastasia S Nikitina^{1

2}, Alexandra V Belodedova³, Boris E Malyugin³, Elena I Sharova¹, Elena S Kostryukova¹, Andrey K Larin¹, Vladimir A Veselovsky¹, Olga P Antonova³, Liubov O Skorodumova¹

Affiliations

¹ Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
² Moscow Institute of Physics and Technology, Dolgoprudnyi, Russia.
³ The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russia.

Abstract

Fuchs endothelial corneal dystrophy (FECD) is a bilateral inherited eye disease with advanced forms only treatable by corneal transplantation. The pathogenesis of FECD has not been worked out yet, however, trinucleotide repeat polymorphism CTG18.1 in the TCF4 gene has recently been associated with late-onset FECD. Gene expression profiling of corneal endothelium with and without this expansion can help elucidate molecular mechanisms of the disease development. Current data article represents whole transcriptome profiles of corneal endothelium obtained from 12 patients with FECD and 6 control tissues from eye bank donors. RNA sequencing data is available at NCBI Sequence Read Archive under Accession No. PRJNA524323. In addition, each patient and donor were genotyped for CTG18.1 expansion and the corresponding numbers of CTG repeats in the TCF4 gene are provided within this article. The dataset includes samples from FECD patients both with and without CTG18.1 expansion.

Keywords: Fuchs endothelial corneal dystrophy; RNA-Seq; Transcriptome.