Mimickers of neuropsychiatric manifestations in systemic lupus erythematosus

Jaqueline Cristina de Amorim; Aline Kuhl Torricelli; Renan Bazuco Frittoli; Aline Tamires Lapa; Sergio San Juan Dertkigil; Fabiano Reis; Lilian Tl Costallat; Marcondes Cavalcante França Junior; Simone Appenzeller

doi:10.1016/j.berh.2019.01.020

Mimickers of neuropsychiatric manifestations in systemic lupus erythematosus

Best Pract Res Clin Rheumatol. 2018 Oct;32(5):623-639. doi: 10.1016/j.berh.2019.01.020. Epub 2019 Feb 22.

Authors

Jaqueline Cristina de Amorim¹, Aline Kuhl Torricelli², Renan Bazuco Frittoli³, Aline Tamires Lapa¹, Sergio San Juan Dertkigil⁴, Fabiano Reis⁴, Lilian Tl Costallat⁵, Marcondes Cavalcante França Junior⁶, Simone Appenzeller⁷

Affiliations

¹ Graduate Program of Child and Adolescent Health, School of Medical Science, University of Campinas, Brazil; Laboratory of Autoimmune Diseases, School of Medical Science, University of Campinas, Brazil.
² Rheumatology Unit, University of São Paulo, Brazil.
³ Laboratory of Autoimmune Diseases, School of Medical Science, University of Campinas, Brazil; Graduate Program of Physiopathology, School of Medical Science, University of Campinas, Brazil.
⁴ Department of Radiology, School of Medical Science, University of Campinas, Brazil.
⁵ Rheumatology Unit, Department of Medicine, School of Medical Science, University of Campinas, Brazil.
⁶ Department of Neurology, School of Medical Science, University of Campinas, Brazil.
⁷ Laboratory of Autoimmune Diseases, School of Medical Science, University of Campinas, Brazil; Rheumatology Unit, Department of Medicine, School of Medical Science, University of Campinas, Brazil. Electronic address: appenzel@unicamp.br.

PMID: 31203921
DOI: 10.1016/j.berh.2019.01.020

Abstract

Systemic lupus erythematosus (SLE), presenting with new onset or worsening neuropsychiatric (NP) symptoms, is a challenge in clinical practice. Mimickers such as infections, drug-induced side effects, metabolic abnormalities, malignancies, and alcohol-related disorders have to be excluded, before attributing the manifestations to disease activity. Proper diagnosis is essential to guide adequate management and reduce morbidity and mortality. In this review article, we will highlight clinical, laboratorial, and neuroradiological features that are helpful to assist in the differential diagnosis.

Keywords: Mimickers; Neuropsychiatric manifestations; Systemic lupus erythematosus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diagnosis, Differential
Female
Humans
Lupus Erythematosus, Systemic / psychology
Lupus Vasculitis, Central Nervous System / diagnosis*